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Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer

BACKGROUND: Limitless self-renewal is one of the hallmarks of cancer and is attained by telomere maintenance, essentially through telomerase (hTERT) activation. Transcriptional regulation of hTERT is believed to play a major role in telomerase activation in human cancers. MAIN BODY: The dominant int...

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Detalles Bibliográficos
Autores principales:	Leão, Ricardo, Apolónio, Joana Dias, Lee, Donghyun, Figueiredo, Arnaldo, Tabori, Uri, Castelo-Branco, Pedro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846307/ https://www.ncbi.nlm.nih.gov/pubmed/29526163 http://dx.doi.org/10.1186/s12929-018-0422-8

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