Microenvironment-driven resistance to B-Raf inhibition in a melanoma patient is accompanied by broad changes of gene methylation and expression in distal fibroblasts

The incidence of malignant melanoma is rapidly increasing and current medicine is offering only limited options for treatment of the advanced disease. For B-Raf mutated melanomas, treatment with mutation-specific drug inhibitors may be used. Unfortunately, tumors frequently acquire resistance to the...

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Detalles Bibliográficos
Autores principales: Kodet, Ondřej, Dvořánková, Barbora, Bendlová, Běla, Sýkorová, Vlasta, Krajsová, Ivana, Štork, Jiří, Kučera, Jan, Szabo, Pavol, Strnad, Hynek, Kolář, Michal, Vlček, Čestmír, Smetana, Karel, Lacina, Lukáš
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846633/
https://www.ncbi.nlm.nih.gov/pubmed/29393387
http://dx.doi.org/10.3892/ijmm.2018.3448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846633/
https://www.ncbi.nlm.nih.gov/pubmed/29393387
http://dx.doi.org/10.3892/ijmm.2018.3448

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