BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation

The controlled release of RNA polymerase II (RNAPII) from promoter-proximal pausing (PPP) sites is critical for transcription elongation in metazoans. We show that the human tumor suppressor BRCA2 interacts with RNAPII to regulate PPP release, thereby preventing unscheduled RNA-DNA hybrids (R-loops)...

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Detalles Bibliográficos
Autores principales: Shivji, Mahmud K.K., Renaudin, Xavier, Williams, Çiğdem H., Venkitaraman, Ashok R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846855/
https://www.ncbi.nlm.nih.gov/pubmed/29386125
http://dx.doi.org/10.1016/j.celrep.2017.12.086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846855/
https://www.ncbi.nlm.nih.gov/pubmed/29386125
http://dx.doi.org/10.1016/j.celrep.2017.12.086

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