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BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation
The controlled release of RNA polymerase II (RNAPII) from promoter-proximal pausing (PPP) sites is critical for transcription elongation in metazoans. We show that the human tumor suppressor BRCA2 interacts with RNAPII to regulate PPP release, thereby preventing unscheduled RNA-DNA hybrids (R-loops)...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846855/ https://www.ncbi.nlm.nih.gov/pubmed/29386125 http://dx.doi.org/10.1016/j.celrep.2017.12.086 |