Pharmacogenetics of thiopurines for inflammatory bowel disease in East Asia: prospects for clinical application of NUDT15 genotyping

The thiopurine drugs 6-mercaptopurine (6-MP) and azathiopurine (AZA) are widely used to treat inflammatory bowel disease. However, the incidence of adverse reactions is high, particularly in Asia, and the mechanisms of toxicity in Asian populations remain unclear. Thiopurine S-methyltransferase (TPM...

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Detalles Bibliográficos
Autores principales: Kakuta, Yoichi, Kinouchi, Yoshitaka, Shimosegawa, Tooru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846876/
https://www.ncbi.nlm.nih.gov/pubmed/29192347
http://dx.doi.org/10.1007/s00535-017-1416-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846876/
https://www.ncbi.nlm.nih.gov/pubmed/29192347
http://dx.doi.org/10.1007/s00535-017-1416-0

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