Cinacalcet corrects hypercalcemia in mice with an inactivating Gα(11) mutation

Loss-of-function mutations of GNA11, which encodes G-protein subunit α(11) (Gα(11)), a signaling partner for the calcium-sensing receptor (CaSR), result in familial hypocalciuric hypercalcemia type 2 (FHH2). FHH2 is characterized by hypercalcemia, inappropriately normal or raised parathyroid hormone...

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Detalles Bibliográficos
Autores principales: Howles, Sarah A., Hannan, Fadil M., Gorvin, Caroline M., Piret, Sian E., Paudyal, Anju, Stewart, Michelle, Hough, Tertius A., Nesbit, M. Andrew, Wells, Sara, Brown, Stephen D.M., Cox, Roger D., Thakker, Rajesh V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846897/
https://www.ncbi.nlm.nih.gov/pubmed/29046478
http://dx.doi.org/10.1172/jci.insight.96540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846897/
https://www.ncbi.nlm.nih.gov/pubmed/29046478
http://dx.doi.org/10.1172/jci.insight.96540

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