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TRPV1 gain-of-function mutation impairs pain and itch sensations in mice

Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel, which can detect various noxious stimuli that cause pain, inflammation, hyperalgesia, and itch. TRPV1 knock-out mice show deficiency in nociception, but the in vivo effects of persistent activation of TRPV1 are not c...

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Detalles Bibliográficos
Autores principales: Duo, Lina, Hu, Linghan, Tian, Naxi, Cheng, Gen, Wang, Huijun, Lin, Zhimiao, Wang, Yun, Yang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846932/
https://www.ncbi.nlm.nih.gov/pubmed/29424270
http://dx.doi.org/10.1177/1744806918762031