Myosin light chain kinase (MYLK) coding polymorphisms modulate human lung endothelial cell barrier responses via altered tyrosine phosphorylation, spatial localization, and lamellipodial protrusions

Sphingosine 1-phosphate (S1P) is a potent bioactive endogenous lipid that signals a rearrangement of the actin cytoskeleton via the regulation of non-muscle myosin light chain kinase isoform (nmMLCK). S1P induces critical nmMLCK Y(464) and Y(471) phosphorylation resulting in translocation of nmMLCK...

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Detalles Bibliográficos
Autores principales: Wang, Ting, Brown, Mary E., Kelly, Gabriel T., Camp, Sara M., Mascarenhas, Joseph B., Sun, Xiaoguang, Dudek, Steven M., Garcia, Joe G.N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846938/
https://www.ncbi.nlm.nih.gov/pubmed/29480069
http://dx.doi.org/10.1177/2045894018764171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846938/
https://www.ncbi.nlm.nih.gov/pubmed/29480069
http://dx.doi.org/10.1177/2045894018764171

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