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Insulin mediates de novo nuclear accumulation of the IGF-1/insulin Hybrid Receptor in corneal epithelial cells

Insulin and insulin-like growth factor-1 (IGF-1) are present in human tears and likely play an important role in mediating ocular surface homeostasis. We previously characterized the IGF-1/insulin hybrid receptor (Hybrid–R) in corneal epithelial cells and found that it was activated by IGF-1 and not...

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Detalles Bibliográficos
Autores principales: Titone, Rossella, Zhu, Meifang, Robertson, Danielle M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847585/
https://www.ncbi.nlm.nih.gov/pubmed/29531349
http://dx.doi.org/10.1038/s41598-018-21031-7