Artificial cationic oligosaccharides for heteroduplex oligonucleotide-type drugs

Heteroduplex oligonucleotides (HDOs), composed of a DNA/LNA gapmer and its complementary RNA, are a novel, promising candidates for antisense drugs. We previously reported oligodiaminogalactoses (ODAGals), designed to bind to A-type nucleic acid duplexes such as DNA/RNA and RNA/RNA duplexes. In this...

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Detalles Bibliográficos
Autores principales: Hara, Rintaro Iwata, Hisada, Yuki, Maeda, Yusuke, Yokota, Takanori, Wada, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847598/
https://www.ncbi.nlm.nih.gov/pubmed/29531343
http://dx.doi.org/10.1038/s41598-018-22161-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847598/
https://www.ncbi.nlm.nih.gov/pubmed/29531343
http://dx.doi.org/10.1038/s41598-018-22161-8

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