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Vesicular glutamate release from central axons contributes to myelin damage

The axon myelin sheath is prone to injury associated with N-methyl-d-aspartate (NMDA)-type glutamate receptor activation but the source of glutamate in this context is unknown. Myelin damage results in permanent action potential loss and severe functional deficit in the white matter of the CNS, for...

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Detalles Bibliográficos
Autores principales: Doyle, Sean, Hansen, Daniel Bloch, Vella, Jasmine, Bond, Peter, Harper, Glenn, Zammit, Christian, Valentino, Mario, Fern, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847599/
https://www.ncbi.nlm.nih.gov/pubmed/29531223
http://dx.doi.org/10.1038/s41467-018-03427-1