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Smurf2 regulates stability and the autophagic–lysosomal turnover of lamin A and its disease‐associated form progerin
A‐lamins, encoded by the LMNA gene, are major structural components of the nuclear lamina coordinating essential cellular processes. Mutations in the LMNA gene and/or alterations in its expression levels have been linked to a distinct subset of human disorders, collectively known as laminopathies, a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847874/ https://www.ncbi.nlm.nih.gov/pubmed/29405587 http://dx.doi.org/10.1111/acel.12732 |