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Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery

[Image: see text] Although many new anti-infectives have been discovered and developed solely using phenotypic cellular screening and assay optimization, most researchers recognize that structure-guided drug design is more practical and less costly. In addition, a greater chemical space can be inter...

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Detalles Bibliográficos
Autores principales: Luth, Madeline R., Gupta, Purva, Ottilie, Sabine, Winzeler, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848146/
https://www.ncbi.nlm.nih.gov/pubmed/29451780
http://dx.doi.org/10.1021/acsinfecdis.7b00276