A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin

Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease caused by a truncated lamin A protein (progerin) that drives cellular and organismal decline. HGPS patient-derived fibroblasts accumulate genomic instability, but its underlying mechanisms and contribution to disease remain poo...

Descripción completa

Detalles Bibliográficos
Autores principales: Kreienkamp, Ray, Graziano, Simona, Coll-Bonfill, Nuria, Bedia-Diaz, Gonzalo, Cybulla, Emily, Vindigni, Alessandro, Dorsett, Dale, Kubben, Nard, Batista, Luis Francisco Zirnberger, Gonzalo, Susana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848491/
https://www.ncbi.nlm.nih.gov/pubmed/29466729
http://dx.doi.org/10.1016/j.celrep.2018.01.090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848491/
https://www.ncbi.nlm.nih.gov/pubmed/29466729
http://dx.doi.org/10.1016/j.celrep.2018.01.090

Ejemplares similares