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Sickle Cell Anemia, the First Molecular Disease: Overview of Molecular Etiology, Pathophysiology, and Therapeutic Approaches
The root cause of sickle cell disease is a single β-globin gene mutation coding for the sickle β-hemoglobin chain. Sickle hemoglobin tetramers polymerize when deoxygenated, damaging the sickle erythrocyte. A multifaceted pathophysiology, triggered by erythrocyte injury induced by the sickle hemoglob...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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TheScientificWorldJOURNAL
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848659/ https://www.ncbi.nlm.nih.gov/pubmed/19112541 http://dx.doi.org/10.1100/tsw.2008.157 |