Optical control of GPR40 signalling in pancreatic β-cells

Fatty acids activate GPR40 and K(+) channels to modulate β-cell function. Herein, we describe the design and synthesis of FAAzo-10, a light-controllable GPR40 agonist based on Gw-9508. FAAzo-10 is a potent GPR40 agonist in the trans-configuration and can be inactivated on isomerization to cis with U...

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Detalles Bibliográficos
Autores principales: Frank, James Allen, Yushchenko, Dmytro A., Fine, Nicholas H. F., Duca, Margherita, Citir, Mevlut, Broichhagen, Johannes, Hodson, David J., Schultz, Carsten, Trauner, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848828/
https://www.ncbi.nlm.nih.gov/pubmed/29568424
http://dx.doi.org/10.1039/c7sc01475a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848828/
https://www.ncbi.nlm.nih.gov/pubmed/29568424
http://dx.doi.org/10.1039/c7sc01475a

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