Preclinical pharmacokinetics, interspecies scaling, and pharmacokinetics of a Phase I clinical trial of TTAC-0001, a fully human monoclonal antibody against vascular endothelial growth factor 2

BACKGROUND: VEGF is a highly selective mitogen that serves as the central regulator of tumor angiogenesis by mediating endothelial proliferation, permeability, and survival. Tanibirumab (TTAC-0001) is a fully human IgG1 monoclonal antibody derived from a fully human naïve single-chain variable fragm...

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Detalles Bibliográficos
Autores principales: Lee, Weon Sup, Shim, Sang Ryeol, Lee, Seon Young, Yoo, Jin San, Cho, Sung Kweon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848842/
https://www.ncbi.nlm.nih.gov/pubmed/29563774
http://dx.doi.org/10.2147/DDDT.S150241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848842/
https://www.ncbi.nlm.nih.gov/pubmed/29563774
http://dx.doi.org/10.2147/DDDT.S150241

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