NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins

The DUX4 transcription factor is encoded by a retrogene embedded in each unit of the D4Z4 macrosatellite repeat. DUX4 is normally expressed in the cleavage-stage embryo, whereas chromatin repression prevents DUX4 expression in most somatic tissues. Failure of this repression causes facioscapulohumer...

Descripción completa

Detalles Bibliográficos
Autores principales: Campbell, Amy E, Shadle, Sean C, Jagannathan, Sujatha, Lim, Jong-Won, Resnick, Rebecca, Tawil, Rabi, van der Maarel, Silvère M, Tapscott, Stephen J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849414/
https://www.ncbi.nlm.nih.gov/pubmed/29533181
http://dx.doi.org/10.7554/eLife.31023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849414/
https://www.ncbi.nlm.nih.gov/pubmed/29533181
http://dx.doi.org/10.7554/eLife.31023

Ejemplares similares