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NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins

The DUX4 transcription factor is encoded by a retrogene embedded in each unit of the D4Z4 macrosatellite repeat. DUX4 is normally expressed in the cleavage-stage embryo, whereas chromatin repression prevents DUX4 expression in most somatic tissues. Failure of this repression causes facioscapulohumer...

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Detalles Bibliográficos
Autores principales:	Campbell, Amy E, Shadle, Sean C, Jagannathan, Sujatha, Lim, Jong-Won, Resnick, Rebecca, Tawil, Rabi, van der Maarel, Silvère M, Tapscott, Stephen J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Chromosomes and Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849414/ https://www.ncbi.nlm.nih.gov/pubmed/29533181 http://dx.doi.org/10.7554/eLife.31023

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