Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity

The cysteine protease Caspase-6 (Casp6) is a potential therapeutic target of Alzheimer Disease (AD) and age-dependent cognitive impairment. To assess if Casp6 is essential to human health, we investigated the effect of CASP6 variants sequenced from healthy humans on Casp6 activity. Here, we report t...

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Detalles Bibliográficos
Autores principales: Tubeleviciute-Aydin, Agne, Zhou, Libin, Sharma, Gyanesh, Soni, Ishankumar V., Savinov, Sergey N., Hardy, Jeanne A., LeBlanc, Andrea C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849602/
https://www.ncbi.nlm.nih.gov/pubmed/29535332
http://dx.doi.org/10.1038/s41598-018-22283-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849602/
https://www.ncbi.nlm.nih.gov/pubmed/29535332
http://dx.doi.org/10.1038/s41598-018-22283-z

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