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Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity

The cysteine protease Caspase-6 (Casp6) is a potential therapeutic target of Alzheimer Disease (AD) and age-dependent cognitive impairment. To assess if Casp6 is essential to human health, we investigated the effect of CASP6 variants sequenced from healthy humans on Casp6 activity. Here, we report t...

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Detalles Bibliográficos
Autores principales:	Tubeleviciute-Aydin, Agne, Zhou, Libin, Sharma, Gyanesh, Soni, Ishankumar V., Savinov, Sergey N., Hardy, Jeanne A., LeBlanc, Andrea C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849602/ https://www.ncbi.nlm.nih.gov/pubmed/29535332 http://dx.doi.org/10.1038/s41598-018-22283-z

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