Comparison of metabolic pathways of different α-N-heterocyclic thiosemicarbazones

Clinical failure of novel drugs is often related to their rapid metabolism and excretion. This highlights the importance of elucidation of their pharmacokinetic profile already at the preclinical stage of drug development. Triapine, the most prominent representative of α-N-heterocyclic thiosemicarba...

Descripción completa

Detalles Bibliográficos
Autores principales: Pelivan, Karla, Frensemeier, Lisa M., Karst, Uwe, Koellensperger, Gunda, Heffeter, Petra, Keppler, Bernhard K., Kowol, Christian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849672/
https://www.ncbi.nlm.nih.gov/pubmed/29476231
http://dx.doi.org/10.1007/s00216-018-0889-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849672/
https://www.ncbi.nlm.nih.gov/pubmed/29476231
http://dx.doi.org/10.1007/s00216-018-0889-x

Ejemplares similares