A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis

The Hippo pathway is a central regulator of tissue development and homeostasis, and has been reported to have a role during vascular development. Here we develop a bioluminescence-based biosensor that monitors the activity of the Hippo core component LATS kinase. Using this biosensor and a library o...

Descripción completa

Detalles Bibliográficos
Autores principales: Azad, T., Janse van Rensburg, H. J., Lightbody, E. D., Neveu, B., Champagne, A., Ghaffari, A., Kay, V. R., Hao, Y., Shen, H., Yeung, B., Croy, B. A., Guan, K. L., Pouliot, F., Zhang, J., Nicol, C. J. B., Yang, X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849716/
https://www.ncbi.nlm.nih.gov/pubmed/29535383
http://dx.doi.org/10.1038/s41467-018-03278-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849716/
https://www.ncbi.nlm.nih.gov/pubmed/29535383
http://dx.doi.org/10.1038/s41467-018-03278-w

Ejemplares similares