Frequency of Somatic TP53 Mutations in Combination with Known Pathogenic Mutations in Colon Adenocarcinoma, Non–Small Cell Lung Carcinoma, and Gliomas as Identified by Next-Generation Sequencing

The tumor suppressor gene TP53 is the most frequently mutated gene in human cancer. It encodes p53, a DNA-binding transcription factor that regulates multiple genes involved in DNA repair, metabolism, cell cycle arrest, apoptosis, and senescence. TP53 is associated with human cancer by mutations tha...

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Detalles Bibliográficos
Autores principales: Shajani-Yi, Zahra, de Abreu, Francine B., Peterson, Jason D., Tsongalis, Gregory J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2018
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849803/
https://www.ncbi.nlm.nih.gov/pubmed/29454261
http://dx.doi.org/10.1016/j.neo.2017.12.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849803/
https://www.ncbi.nlm.nih.gov/pubmed/29454261
http://dx.doi.org/10.1016/j.neo.2017.12.005

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