Epigenetic Targeting of Granulin in Hepatoma Cells by Synthetic CRISPR dCas9 Epi-suppressors

The CRISPR-associated Cas9 system can modulate disease-causing alleles both in vivo and ex vivo, raising the possibility of therapeutic genome editing. In addition to gene targeting, epigenetic modulation by the catalytically inactive dCas9 may also be a potential form of cancer therapy. Granulin (G...

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Detalles Bibliográficos
Autores principales: Wang, Hong, Guo, Rui, Du, Zhonghua, Bai, Ling, Li, Lingyu, Cui, Jiuwei, Li, Wei, Hoffman, Andrew R., Hu, Ji-Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849805/
https://www.ncbi.nlm.nih.gov/pubmed/29858058
http://dx.doi.org/10.1016/j.omtn.2018.01.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849805/
https://www.ncbi.nlm.nih.gov/pubmed/29858058
http://dx.doi.org/10.1016/j.omtn.2018.01.002

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