RNA Structure Design Improves Activity and Specificity of trans-Splicing-Triggered Cell Death in a Suicide Gene Therapy Approach

Spliceosome-mediated RNA trans-splicing enables correction or labeling of pre-mRNA, but therapeutic applications are hampered by issues related to the activity and target specificity of trans-splicing RNA (tsRNA). We employed computational RNA structure design to improve both on-target activity and...

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Detalles Bibliográficos
Autores principales: Poddar, Sushmita, Loh, Pei She, Ooi, Zi Hao, Osman, Farhana, Eul, Joachim, Patzel, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849863/
https://www.ncbi.nlm.nih.gov/pubmed/29858076
http://dx.doi.org/10.1016/j.omtn.2018.01.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849863/
https://www.ncbi.nlm.nih.gov/pubmed/29858076
http://dx.doi.org/10.1016/j.omtn.2018.01.006

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