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Regulation of transforming growth factor is involved in the efficacy of combined 5-fluorouracil and interferon alpha-2b therapy of advanced hepatocellular carcinoma

Transforming growth factor-beta (TGF-β) is critical in cancer cell invasion and metastasis. The effects of a treatment that targets TGF-β using the combination of interferon alpha (IFNα)-2b and 5-fluorouracil (5-FU) are unknown. Here, we show that the serum levels of TGF-β1 prior to the therapy corr...

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Detalles Bibliográficos
Autores principales: Okada, Youhei, Wang, Ting, Kasai, Kazuhiro, Suzuki, Kazuyuki, Takikawa, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849890/
https://www.ncbi.nlm.nih.gov/pubmed/29560281
http://dx.doi.org/10.1038/s41420-018-0040-y