Design of pH-sensitive methotrexate prodrug-targeted curcumin nanoparticles for efficient dual-drug delivery and combination cancer therapy

AIM: We designed acid-labile methotrexate (MTX) targeting prodrug self-assembling nanoparticles loaded with curcumin (CUR) drug for simultaneous delivery of multi-chemotherapeutic drugs and combination cancer therapy. METHODS: A dual-acting MTX, acting as both an anticancer drug and as a tumor-targe...

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Detalles Bibliográficos
Autores principales: Xie, Jiajiang, Fan, Zhongxiong, Li, Yang, Zhang, Yinying, Yu, Fei, Su, Guanghao, Xie, Liya, Hou, Zhenqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849920/
https://www.ncbi.nlm.nih.gov/pubmed/29563794
http://dx.doi.org/10.2147/IJN.S152312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849920/
https://www.ncbi.nlm.nih.gov/pubmed/29563794
http://dx.doi.org/10.2147/IJN.S152312

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