Optimization of Polycistronic Anti-CCR5 Artificial microRNA Leads to Improved Accuracy of Its Lentiviral Vector Transfer and More Potent Inhibition of HIV-1 in CD4(+) T-Cells

C-C chemokine receptor type 5 (CCR5) is utilized by human immunodeficiency virus (HIV) as a co-receptor for cell entry. Suppression of the CCR5 gene by artificial microRNAs (amiRNAs) could confer cell resistance. In previous work, we created a lentivector that encoded the polycistron of two identica...

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Detalles Bibliográficos
Autores principales: Urusov, Felix, Glazkova, Dina, Omelchenko, Denis, Bogoslovskaya, Elena, Tsyganova, Galina, Kersting, Katerina, Shipulin, German, Pokrovsky, Vadim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850098/
https://www.ncbi.nlm.nih.gov/pubmed/29401717
http://dx.doi.org/10.3390/cells7020010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850098/
https://www.ncbi.nlm.nih.gov/pubmed/29401717
http://dx.doi.org/10.3390/cells7020010

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