Nutrient Limitation Inactivates Mrc1-to-Cds1 Checkpoint Signalling in Schizosaccharomyces pombe

The S. pombe checkpoint kinase, Cds1, protects the integrity of stalled DNA replication forks after its phosphorylation at threonine-11 by Rad3 (ATR). Modified Cds1 associates through its N-terminal forkhead-associated domain (FHA)-domain with Mrc1 (Claspin) at stalled forks. We report here that nut...

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Detalles Bibliográficos
Autores principales: Fletcher, Jessica, Griffiths, Liam, Caspari, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850103/
https://www.ncbi.nlm.nih.gov/pubmed/29473861
http://dx.doi.org/10.3390/cells7020015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850103/
https://www.ncbi.nlm.nih.gov/pubmed/29473861
http://dx.doi.org/10.3390/cells7020015

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