Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro

BACKGROUND: Transient receptor potential vanilloid 2 is a calcium channel activated by probenecid. Probenecid is a Food and Drug Administration–approved uricosuric drug that has recently been shown to induce positive lusitropic and inotropic effects in animal models through cardiomyocyte transient r...

Descripción completa

Detalles Bibliográficos
Autores principales: Robbins, Nathan, Gilbert, Mark, Kumar, Mohit, McNamara, James W., Daly, Patrick, Koch, Sheryl E., Conway, Ginger, Effat, Mohamed, Woo, Jessica G., Sadayappan, Sakthivel, Rubinstein, Jack
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850150/
https://www.ncbi.nlm.nih.gov/pubmed/29331959
http://dx.doi.org/10.1161/JAHA.117.007148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850150/
https://www.ncbi.nlm.nih.gov/pubmed/29331959
http://dx.doi.org/10.1161/JAHA.117.007148

Ejemplares similares