Genetic and Pharmacologic Inhibition of the Neutrophil Elastase Inhibits Experimental Atherosclerosis

BACKGROUND: To investigate whether neutrophil elastase (NE) plays a causal role in atherosclerosis, and the molecular mechanisms involved. METHODS AND RESULTS: NE genetic–deficient mice (Apolipoprotein E(−/−)/NE (−/−) mice), bone marrow transplantation, and a specific NE inhibitor (GW311616A) were e...

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Detalles Bibliográficos
Autores principales: Wen, Guanmei, An, Weiwei, Chen, Jiangyong, Maguire, Eithne M., Chen, Qishan, Yang, Feng, Pearce, Stuart W. A., Kyriakides, Maria, Zhang, Li, Ye, Shu, Nourshargh, Sussan, Xiao, Qingzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850208/
https://www.ncbi.nlm.nih.gov/pubmed/29437605
http://dx.doi.org/10.1161/JAHA.117.008187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850208/
https://www.ncbi.nlm.nih.gov/pubmed/29437605
http://dx.doi.org/10.1161/JAHA.117.008187

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