Recombinant Human ADAMTS13 Treatment Improves Myocardial Remodeling and Functionality After Pressure Overload Injury in Mice

BACKGROUND: A disintegrin‐like metalloproteinase with thrombospondin motif type 1 member 13 (ADAMTS13), the von Willebrand factor–cleaving enzyme, decreases leukocyte and platelet recruitment and, thus, reduces thrombosis and inflammation. Recombinant human ADAMTS13 (rhADAMTS13) is a novel drug cand...

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Detalles Bibliográficos
Autores principales: Witsch, Thilo, Martinod, Kimberly, Sorvillo, Nicoletta, Portier, Irina, De Meyer, Simon F., Wagner, Denisa D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850234/
https://www.ncbi.nlm.nih.gov/pubmed/29367415
http://dx.doi.org/10.1161/JAHA.117.007004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850234/
https://www.ncbi.nlm.nih.gov/pubmed/29367415
http://dx.doi.org/10.1161/JAHA.117.007004

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