Inhibiting Integrin α5 Cytoplasmic Domain Signaling Reduces Atherosclerosis and Promotes Arteriogenesis

BACKGROUND: Fibronectin in endothelial basement membranes promotes endothelial inflammatory activation and atherosclerosis but also promotes plaque stability and vascular remodeling. The fibronectin receptor α5 subunit is proinflammatory through binding to and activating phosphodiesterase 4D5, which...

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Detalles Bibliográficos
Autores principales: Budatha, Madhusudhan, Zhang, Jiasheng, Zhuang, Zhen W., Yun, Sanguk, Dahlman, James E., Anderson, Daniel G., Schwartz, Martin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850249/
https://www.ncbi.nlm.nih.gov/pubmed/29382667
http://dx.doi.org/10.1161/JAHA.117.007501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850249/
https://www.ncbi.nlm.nih.gov/pubmed/29382667
http://dx.doi.org/10.1161/JAHA.117.007501

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