Antigenic Variation in Streptococcus pneumoniae PspC Promotes Immune Escape in the Presence of Variant-Specific Immunity

Genomic analysis reveals extensive sequence variation and hot spots of recombination in surface proteins of Streptococcus pneumoniae. While this phenomenon is commonly attributed to diversifying selection by host immune responses, there is little mechanistic evidence for the hypothesis that diversif...

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Detalles Bibliográficos
Autores principales: Georgieva, M., Kagedan, L., Lu, Ying-Jie, Thompson, C. M., Lipsitch, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850329/
https://www.ncbi.nlm.nih.gov/pubmed/29535198
http://dx.doi.org/10.1128/mBio.00264-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850329/
https://www.ncbi.nlm.nih.gov/pubmed/29535198
http://dx.doi.org/10.1128/mBio.00264-18

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