Development and Validation of a Novel Dual Luciferase Reporter Gene Assay to Quantify Ebola Virus VP24 Inhibition of IFN Signaling

The interferon (IFN) system is the first line of defense against viral infections. Evasion of IFN signaling by Ebola viral protein 24 (VP24) is a critical event in the pathogenesis of the infection and, hence, VP24 is a potential target for drug development. Since no drugs target VP24, the identific...

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Detalles Bibliográficos
Autores principales: Fanunza, Elisa, Frau, Aldo, Sgarbanti, Marco, Orsatti, Roberto, Corona, Angela, Tramontano, Enzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850405/
https://www.ncbi.nlm.nih.gov/pubmed/29495311
http://dx.doi.org/10.3390/v10020098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850405/
https://www.ncbi.nlm.nih.gov/pubmed/29495311
http://dx.doi.org/10.3390/v10020098

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