Experimental Determination and Prediction of the Fitness Effects of Random Point Mutations in the Biosynthetic Enzyme HisA

The distribution of fitness effects of mutations is a factor of fundamental importance in evolutionary biology. We determined the distribution of fitness effects of 510 mutants that each carried between 1 and 10 mutations (synonymous and nonsynonymous) in the hisA gene, encoding an essential enzyme...

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Detalles Bibliográficos
Autores principales: Lundin, Erik, Tang, Po-Cheng, Guy, Lionel, Näsvall, Joakim, Andersson, Dan I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850734/
https://www.ncbi.nlm.nih.gov/pubmed/29294020
http://dx.doi.org/10.1093/molbev/msx325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850734/
https://www.ncbi.nlm.nih.gov/pubmed/29294020
http://dx.doi.org/10.1093/molbev/msx325

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