Modulation of cAMP and Ras Signaling Pathways Improves Distinct Behavioral Deficits in a Zebrafish Model of Neurofibromatosis Type 1

Neurofibromatosis type 1 (NF1) is a common autosomal-dominant disorder associated with attention deficits and learning disabilities. The primary known function of neurofibromin, encoded by the NF1 gene, is to downregulate Ras activity. We show that nf1-deficient zebrafish exhibit learning and memory...

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Detalles Bibliográficos
Autores principales: Wolman, Marc A., de Groh, Eric D., McBride, Sean M., Jongens, Thomas A., Granato, Michael, Epstein, Jonathan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850931/
https://www.ncbi.nlm.nih.gov/pubmed/25176649
http://dx.doi.org/10.1016/j.celrep.2014.07.054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850931/
https://www.ncbi.nlm.nih.gov/pubmed/25176649
http://dx.doi.org/10.1016/j.celrep.2014.07.054

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