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Methylglyoxal-bis-guanylhydrazone inhibits osteopontin expression and differentiation in cultured human monocytes

Monocyte activation and polarization play essential roles in many chronic inflammatory diseases. An imbalance of M1 and M2 macrophage activation (pro-inflammatory and alternatively activated, respectively) is believed to be a key aspect in the etiology of these diseases, thus a therapeutic approach...

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Detalles Bibliográficos
Autores principales: Jin, Xia, Xu, Hua, McGrath, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851547/
https://www.ncbi.nlm.nih.gov/pubmed/29538412
http://dx.doi.org/10.1371/journal.pone.0192680