Biomolecular study of human thymidylate synthase conformer-selective inhibitors: New chemotherapeutic approach

Thymidylate synthase (TS) is a well-validated target for the therapy of adult cancers. Propane-1,3-diphosphonic acid (PDPA) has significant inhibitory properties against human thymidylate synthase (hTS) relative to mouse TS which is not predicted to adopt an inactive conformer. The current research...

Descripción completa

Detalles Bibliográficos
Autores principales: El-Mesallamy, Hala O., El Magdoub, Hekmat M., Chapman, James M., Hamdy, Nadia M., Schaalan, Mona F., Hammad, Lamiaa N., Berger, Sondra H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851609/
https://www.ncbi.nlm.nih.gov/pubmed/29538414
http://dx.doi.org/10.1371/journal.pone.0193810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851609/
https://www.ncbi.nlm.nih.gov/pubmed/29538414
http://dx.doi.org/10.1371/journal.pone.0193810

Ejemplares similares