Development of Potent Inhibitors of Receptor Tyrosine Kinases by Ligand-Based Drug Design and Target-Biased Phenotypic Screening

[Image: see text] Pyrazolopyrimidines with potent antiproliferative properties were developed by an adaptive strategy that applies ligand-based design and phenotypic screening iteratively and is informed by biochemical assays. To drive development toward specific oncopathways, compounds were tested...

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Detalles Bibliográficos
Autores principales: Myers, Samuel H., Temps, Carolin, Houston, Douglas R., Brunton, Valerie G., Unciti-Broceta, Asier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851644/
https://www.ncbi.nlm.nih.gov/pubmed/29466002
http://dx.doi.org/10.1021/acs.jmedchem.7b01605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851644/
https://www.ncbi.nlm.nih.gov/pubmed/29466002
http://dx.doi.org/10.1021/acs.jmedchem.7b01605

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