Cargando…
TANGO1 builds a machine for collagen export by recruiting and spatially organizing COPII, tethers and membranes
Collagen export from the endoplasmic reticulum (ER) requires TANGO1, COPII coats, and retrograde fusion of ERGIC membranes. How do these components come together to produce a transport carrier commensurate with the bulky cargo collagen? TANGO1 is known to form a ring that corrals COPII coats, and we...
Autores principales: | Raote, Ishier, Ortega-Bellido, Maria, Santos, António JM, Foresti, Ombretta, Zhang, Chong, Garcia-Parajo, Maria F, Campelo, Felix, Malhotra, Vivek |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851698/ https://www.ncbi.nlm.nih.gov/pubmed/29513218 http://dx.doi.org/10.7554/eLife.32723 |
Ejemplares similares
-
A physical mechanism of TANGO1-mediated bulky cargo export
por: Raote, Ishier, et al.
Publicado: (2020) -
TANGO1 assembles into rings around COPII coats at ER exit sites
por: Raote, Ishier, et al.
Publicado: (2017) -
TANGO1 recruits ERGIC membranes to the endoplasmic reticulum for procollagen export
por: Santos, António JM, et al.
Publicado: (2015) -
Biallelic TANGO1 mutations cause a novel syndromal disease due to hampered cellular collagen secretion
por: Lekszas, Caroline, et al.
Publicado: (2020) -
TANGO1 membrane helices create a lipid diffusion barrier at curved membranes
por: Raote, Ishier, et al.
Publicado: (2020)