The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway

Disruption of the mucosal barrier following intestinal ischemia reperfusion (I/R) is life threatening in clinical practice. Mitochondrial dysfunction and oxidative stress significantly contribute to the early phase of I/R injury and amplify the inflammatory response. MitoQ is a mitochondrially targe...

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Detalles Bibliográficos
Autores principales: Hu, Qiongyuan, Ren, Jianan, Li, Guanwei, Wu, Jie, Wu, Xiuwen, Wang, Gefei, Gu, Guosheng, Ren, Huajian, Hong, Zhiwu, Li, Jieshou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851994/
https://www.ncbi.nlm.nih.gov/pubmed/29540694
http://dx.doi.org/10.1038/s41419-018-0436-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851994/
https://www.ncbi.nlm.nih.gov/pubmed/29540694
http://dx.doi.org/10.1038/s41419-018-0436-x

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