Inhibition of p70 S6 kinase activity by A77 1726 induces autophagy and enhances the degradation of superoxide dismutase 1 (SOD1) protein aggregates

Autophagy plays a central role in degrading misfolded proteins such as mutated superoxide dismutase 1 (SOD1), which forms aggregates in motor neurons and is involved in the pathogenesis of amyotrophic lateral sclerosis (ALS). Autophagy is activated when UNC-51-like kinase 1 (ULK1) is phosphorylated...

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Detalles Bibliográficos
Autores principales: Sun, Jing, Mu, Yarong, Jiang, Yuanyuan, Song, Ruilong, Yi, Jianxin, Zhou, Jingsong, Sun, Jun, Jiao, Xinan, Prinz, Richard A., Li, Yi, Xu, Xiulong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851998/
https://www.ncbi.nlm.nih.gov/pubmed/29540819
http://dx.doi.org/10.1038/s41419-018-0441-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851998/
https://www.ncbi.nlm.nih.gov/pubmed/29540819
http://dx.doi.org/10.1038/s41419-018-0441-0

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