miR-3140 suppresses tumor cell growth by targeting BRD4 via its coding sequence and downregulates the BRD4-NUT fusion oncoprotein

Bromodomain Containing 4 (BRD4) mediates transcriptional elongation of the oncogene MYC by binding to acetylated histones. BRD4 has been shown to play a critical role in tumorigenesis in several cancers, and the BRD4-NUT fusion gene is a driver of NUT midline carcinoma (NMC), a rare but highly letha...

Descripción completa

Detalles Bibliográficos
Autores principales: Tonouchi, Erina, Gen, Yasuyuki, Muramatsu, Tomoki, Hiramoto, Hidekazu, Tanimoto, Kousuke, Inoue, Jun, Inazawa, Johji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852021/
https://www.ncbi.nlm.nih.gov/pubmed/29540837
http://dx.doi.org/10.1038/s41598-018-22767-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852021/
https://www.ncbi.nlm.nih.gov/pubmed/29540837
http://dx.doi.org/10.1038/s41598-018-22767-y

Ejemplares similares