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miR-3140 suppresses tumor cell growth by targeting BRD4 via its coding sequence and downregulates the BRD4-NUT fusion oncoprotein

Bromodomain Containing 4 (BRD4) mediates transcriptional elongation of the oncogene MYC by binding to acetylated histones. BRD4 has been shown to play a critical role in tumorigenesis in several cancers, and the BRD4-NUT fusion gene is a driver of NUT midline carcinoma (NMC), a rare but highly letha...

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Detalles Bibliográficos
Autores principales:	Tonouchi, Erina, Gen, Yasuyuki, Muramatsu, Tomoki, Hiramoto, Hidekazu, Tanimoto, Kousuke, Inoue, Jun, Inazawa, Johji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852021/ https://www.ncbi.nlm.nih.gov/pubmed/29540837 http://dx.doi.org/10.1038/s41598-018-22767-y

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