Dopamine D1 receptor density in the mPFC responds to cognitive demands and receptor turnover contributes to general cognitive ability in mice

In both humans and mice, performance on tests of intelligence or general cognitive ability (GCA) is related to dopamine D1 receptor-mediated activity in the prelimbic cortex, and levels of DRD1 mRNA predict the GCA of mice. Here we assessed the turnover rate of D1 receptors as well as the expression...

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Detalles Bibliográficos
Autores principales: Wass, Christopher, Sauce, Bruno, Pizzo, Alessandro, Matzel, Louis D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852043/
https://www.ncbi.nlm.nih.gov/pubmed/29540721
http://dx.doi.org/10.1038/s41598-018-22668-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852043/
https://www.ncbi.nlm.nih.gov/pubmed/29540721
http://dx.doi.org/10.1038/s41598-018-22668-0

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