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cAMP Catalyzing Phosphodiesterases Control Cholinergic Muscular Activity But Their Inhibition Does Not Enhance 5-HT(4) Receptor-Mediated Facilitation of Cholinergic Contractions in the Murine Gastrointestinal Tract

Background: As the signal transduction of 5-HT(4) receptors on cholinergic neurons innervating smooth muscle is controlled by phosphodiesterase (PDE) 4 in porcine stomach and colon, and human large intestine, the in vivo gastroprokinetic effects of a 5-HT(4) receptor agonist might be enhanced by com...

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Detalles Bibliográficos
Autores principales: Pauwelyn, Vicky, Lefebvre, Romain A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852062/
https://www.ncbi.nlm.nih.gov/pubmed/29568269
http://dx.doi.org/10.3389/fphar.2018.00171