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cAMP Catalyzing Phosphodiesterases Control Cholinergic Muscular Activity But Their Inhibition Does Not Enhance 5-HT(4) Receptor-Mediated Facilitation of Cholinergic Contractions in the Murine Gastrointestinal Tract
Background: As the signal transduction of 5-HT(4) receptors on cholinergic neurons innervating smooth muscle is controlled by phosphodiesterase (PDE) 4 in porcine stomach and colon, and human large intestine, the in vivo gastroprokinetic effects of a 5-HT(4) receptor agonist might be enhanced by com...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852062/ https://www.ncbi.nlm.nih.gov/pubmed/29568269 http://dx.doi.org/10.3389/fphar.2018.00171 |