Circular DNA elements of chromosomal origin are common in healthy human somatic tissue

The human genome is generally organized into stable chromosomes, and only tumor cells are known to accumulate kilobase (kb)-sized extrachromosomal circular DNA elements (eccDNAs). However, it must be expected that kb eccDNAs exist in normal cells as a result of mutations. Here, we purify and sequenc...

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Detalles Bibliográficos
Autores principales: Møller, Henrik Devitt, Mohiyuddin, Marghoob, Prada-Luengo, Iñigo, Sailani, M. Reza, Halling, Jens Frey, Plomgaard, Peter, Maretty, Lasse, Hansen, Anders Johannes, Snyder, Michael P., Pilegaard, Henriette, Lam, Hugo Y. K., Regenberg, Birgitte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852086/
https://www.ncbi.nlm.nih.gov/pubmed/29540679
http://dx.doi.org/10.1038/s41467-018-03369-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852086/
https://www.ncbi.nlm.nih.gov/pubmed/29540679
http://dx.doi.org/10.1038/s41467-018-03369-8

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